相关实验视频

Updated: Jun 5, 2025

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

在新生儿重症监护病房中传播疫苗菌株罗塔病毒的风险,该病房经常接种疫苗

Morgan A Zalot¹, Margaret M Cortese², Kevin P O'Callaghan^1,3

¹Department of Pediatrics, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania.

|December 9, 2024

概括

在新生儿重症监护室 (NICU) 施用罗塔病毒疫苗 (RV5) 是安全的,对未接种疫苗的婴儿的传播风险非常低. 在NICU内接种疫苗为轮状病毒保护提供了显著的好处,超过了最小的传播担忧.

科学领域:

新生儿科学新生儿科学
传染性疾病传染性疾病
疫苗学疫苗学疫苗学

背景情况:

新生儿重症监护室 (NICU) 由于理论上存在横向传播风险,经常拒绝接种轮状病毒疫苗.
这项研究涉及在NICU环境中五价性轮状病毒疫苗 (RV5) 的安全性和传播.

研究的目的:

为了确定轮状病毒疫苗 (RV5) 菌株传播给未接种疫苗的婴儿在NICU中的发生率.
评估任何观察到的疫苗菌株传播的临床意义.

主要方法:

在100个床位的NICU中进行了一年的前性队列研究.
每周收集便样本和实时定量逆转录聚合酶连锁反应 (RT-qPCR) 以检测RV5.
发病率计算基于患者有风险的日子;对传播事件的地理空间分析.

主要成果:

对226名婴儿注射RV5;检测了3448个便样本.
在686名未接种疫苗的婴儿中,只有5人 (<1%) 呈RV5菌株阳性.
估计的传播率为2.2/1000患者危险日,没有相关的胃肠炎症状.

结论:

在NICU环境中,rotavirus疫苗 (RV5) 菌株的传播很少发生.
观察到的传播没有临床后果,支持在NICU接种疫苗.
早期的轮状病毒保护的好处超过了疫苗菌株传播的风险.

更多相关视频

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

相关概念视频

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

Vaccinations

Vaccinations