相关实验视频

Updated: Jun 5, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

对B细胞非霍奇金淋巴瘤的表观遗传疗法的进展

Weiwen Hu^1,2, Lanlan Zang³, Xiaoxi Feng^1,2

¹School of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, Shandong, China.

Annals of hematology

|December 9, 2024

概括

表观遗传变化驱动B细胞非霍奇金淋巴瘤 (B-NHLs),导致药物耐药性. 针对这些表观遗传机制为B-NHLs提供了新的治疗策略.

科学领域:

血液学血液学血液学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

B细胞非霍奇金淋巴瘤 (B-NHLs) 是B淋巴细胞的癌症,通常起源于生殖中心.
标准化疗免疫疗法初步有效,但在30%-40%高风险患者中面临药物耐药性挑战.
表观遗传失调,包括DNA甲基化和染色质重塑,在B-NHL发育中越来越被认可.

研究的目的:

检查表观遗传调节在B-NHLs开始和进展中的作用.
审查当前的治疗点和调节B-NHLs表观遗传机制的药物.
探索B-NHL治疗的新疗法和组合策略.

主要方法:

对近期关于B-NHLs表观遗传学研究的文献综述.
对B-NHLs的表观遗传疗法的临床研究分析.
综合有关治疗点和与表观遗传机制相关的药物信息.

主要成果:

诸如DNA甲基化,基因组修饰,非编码RNA调节和染色质重塑等表观遗传过程与B-NHL发育有着显著的联系.
表观遗传向疗法在临床研究中显示出有前途的潜力.
了解这些机制为开发新的向治疗提供了基础.

结论:

表观遗传调节在B-NHLs的发病过程中起着至关重要的作用.
向表观遗传机制代表了新型B-NHL疗法的有希望的途径.
涉及表观遗传剂的组合化疗可能会改善B-NHLs的治疗结果.

关键词:

B-NHLs是什么意思表观遗传药物是一种表观遗传药物.表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.有针对性的治疗.

更多相关视频

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...