生育预测器 - 一个基于机器学习的网络工具,用于预测Y染色体微删除的男性的辅助生殖结果
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Stacy Colaco1, Priyanka Narad2, Ajit Kumar Singh3
1Molecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, JM Street, Parel, Mumbai, Maharashtra, 400012, India.
Journal of assisted reproduction and genetics
|December 9, 2024
概括
一个新的机器学习工具,FertilitY Predictor,可以对Y染色体微删除 (YCMD) 进行分类,并预测辅助生殖成功率. 这种工具有助于评估YCMD男性的精子采集和活产概率.
科学领域:
- 遗传学 遗传学 是一个
- 生殖医学 生殖医学
- 生物信息学是一种生物信息学.
背景情况:
- Y染色体微切除 (YCMD) 是男性不孕症的一个重要原因,特别是精和精.
- 预测YCMD男性辅助生殖技术 (ART) 的结果对于治疗计划至关重要.
研究的目的:
- 开发一种基于机器学习的网络工具,用于预测YCMD男性的精子采集和ART成功率.
- 为了分类不同类型的YCMD,包括AZFa,AZFb,AZFc,它们的组合,和gr/gr删除.
主要方法:
- 对已发表的研究进行了系统审查,以提取YCMD男性的ART结果.
- 机器学习算法被用来开发一个基于Web的预测工具,使用提取的数据.
- 该工具根据遗传标记对YCMD类型进行分类,并预测ART成功概率.
主要成果:
- 生育预测器准确地对YCMD类型进行分类 (AZFa,AZFb,AZFc,gr/gr删除).
- 该工具在预测精子采集,临床怀孕和活产率方面表现出高度准确性.
- 预测表明,精子检索机会因删除类型而异,AZF删除男性的怀孕和活产率较低.
结论:
- 生育预测器有效地分类YCMD并预测ART结果.
- 该工具为管理YCMD导致的男性不孕症和指导ART决策提供了有价值的见解.
关键词:
在这里,我们可以看到AIAIAI.在AZF中微切除.在AZFaFa中,AZFa是AZFa.美国AZFbb美国AZFcc人工智能的人工智能是人工智能.临床怀孕 临床怀孕在受精过程中,受精遗传学 遗传学 是一个在这个过程中,IVF IVF.活生生的出生是活生生的出生.男人不孕不育的情况精子采集 精子采集gr/grgrgr/grgr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr/gr
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02:19The Y Chromosome Determines Maleness
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The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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