肠道微生物群和乳腺癌:系统审查和元分析
Guilherme Gamba1, Tamy Colonetti1, Maria Laura Rodrigues Uggioni1
1Laboratory of Translational Biomedicine, Universidade do Extremo Sul Catarinense, Criciuma, SC, 88806-000, Brazil.
Breast cancer (Tokyo, Japan)
|December 9, 2024
概括
这项研究发现,与健康个体相比,乳腺癌患者的肠道微生物群多样性减少了. 这些发现表明,肠道微生物组可能会影响乳腺癌的发展.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道微生物群影响全身雌激素水平,可能影响雌激素驱动的乳腺癌.
- 肠道微生物群组成的变化越来越多地与各种疾病有关,包括癌症.
研究的目的:
- 研究和评估乳腺癌患者肠道微生物群的变化.
- 为了确定肠道微生物群的多样性是否在患有乳腺癌的女性和健康对照群之间有所不同.
主要方法:
- 进行了系统的文献搜索,使用与微生物群和乳腺癌相关的术语.
- 十项包括1730名女性 (929例,801例对照) 的观察性研究被纳入了元分析.
主要成果:
- 总的来说,与对照组 (SMD -0.34) 相比,乳腺癌患者的肠道微生物群多样性显著减少 (香农指数).
- 患有乳腺癌的绝经前妇女在肠道微生物多样性显著下降 (SMD -0.67).
- 下肠道微生物多样性也观察到女性的体重指数 (BMI) 在18.5和25.0之间 (SMD -0.49).
结论:
- 乳腺癌患者和对照组之间存在肠道微生物群多样性的显著差异.
- 这些发现支持了肠道微生物群在乳腺癌发生过程中发挥作用的假设.
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