益生菌补充剂有益于牛皮治疗,而不是影响疾病风险:来自NHANES机器学习和元分析研究的证据
Yajia Li1,2, Xiao Liu2,3, Ziqin Cao4,5
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Probiotics and antimicrobial proteins
|December 9, 2024
概括
益生菌补充剂不会降低牛皮风险,但可以显著改善疾病的严重程度. 一项大型研究和分析显示,益生菌降低了牛皮病区域和严重性指数 (PASI) 的得分,并提高了治疗反应.
科学领域:
- 皮肤病学和胃肠病学
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,对生活质量产生重大影响.
- 肠道微生物群和益生菌补充剂在治疗牛皮的作用是一个正在进行的研究领域.
- 目前关于益生菌在牛皮的疗效的证据需要进一步调查,特别是关于疾病风险和严重程度.
研究的目的:
- 调查益生菌摄入量与患上牛皮的风险之间的关联.
- 评估益生菌补充剂对牛皮严重程度,生活质量和炎症标志物的影响.
- 通过元分析综合现有证据,以提供关于益生菌疗效的强有力的结论.
主要方法:
- 使用机器学习技术,对来自国家健康和营养检查调查 (NHANES) 的大量队列 (n=21,942) 进行分析.
- 对评估益生菌对牛皮区域和严重性指数 (PASI) 评分,生活质量和炎症标志物的影响的研究的元分析.
- 使用几率比率 (ORs) 进行统计分析,对二分法数据使用95%的置信区间 (CI).
主要成果:
- 在NHANES数据分析中,没有发现益生菌消费与减少牛皮风险之间的显著联系.
- 分析显示,益生菌补充剂显著降低了PASI分数,并改善了PASI75和清除率.
- 益生菌证明了炎症标志物的减少,在治疗后的数据中注意到生活质量的改善.
结论:
- 益生菌补充剂在减少牛皮的严重程度方面显示出显著的治疗益处.
- 根据目前的证据,益生菌似乎不能降低患上牛皮的风险.
- 进一步的研究可能会探索特定的益生菌菌株和银病管理的机制.
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