艾滋病毒,肠道微生物群和临床结果,系统性审查
Rachel Mac Cann1,2,3, Ellen Newman2, Declan Devane4
1School of Medicine, University College Dublin, Dublin 4, Ireland.
PloS one
|December 9, 2024
概括
艾滋病毒感染者 (PWH) 面临着加速衰老和并发症,与肠道微生物组变化有关. 本综述强调了在PWH中肠道失调和非传染性疾病 (NCD) 之间的关联.
科学领域:
- 微生物组研究 微生物组研究
- 艾滋病毒 医学 艾滋病毒 医学
- 免疫学 免疫学 免疫学
背景情况:
- 有效的抗逆转录病毒疗法 (ART) 增加了艾滋病毒的存活率,但加速了与年龄相关的并发症.
- 慢性免疫激活,炎症和肠道微生物组失调有助于艾滋病毒 (PWH) 感染者的这些并发症.
研究的目的:
- 在PWH中系统地审查肠道微生物组失调和非传染性疾病 (NCD) 之间的关联.
- 为了确定关键的微生物标记物和代谢物与PWH中NCD相关.
主要方法:
- 在PubMed,Embase,Scopus,Cochrane评论和会议摘要的系统文献搜索.
- 包括的研究检查了NCDs (心血管,癌症,虚弱,代谢,骨,脏,神经认知) 在PWH (>18年).
- 研究测量了肠道微生物群的多样性,组成,微生物转移或代谢物标记.
主要成果:
- 包括56篇文章,表明PWH中非传染性疾病,特别是心血管和代谢疾病的负担很高.
- 观察到肠道细菌多样性的减少和细菌丰度的改变.
- 脂聚糖,可溶性CD14,短链脂肪酸,三和胆代谢物与非传染性疾病有关.
结论:
- 这是第一个总结肠道微生物和NCD在PWH中的关联的系统性审查.
- 了解这种相互作用,可以了解NCD的发病过程以及PWH的潜在诊断/治疗策略.
相关概念视频
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