血清甲状腺激素水平与自闭症幼儿症状严重程度之间的关系
Maria Kopcikova1, Barbara Raskova1, Ivan Belica1
11Faculty of Medicine, Institute of Physiology, Comenius University, Bratislava, Slovakia.
Endocrine regulations
|December 9, 2024
概括
在患有自闭症谱系障碍 (ASD) 的儿童中,甲状腺激素水平正常. 然而,较低的甲状腺刺激激素 (TSH) 和自由三甲状腺素 (fT3) 与更严重的ASD症状,特别是社交和沟通障碍有关.
科学领域:
- 神经内分泌学神经内分泌学
- 发育儿科 发育儿科
- 自闭症谱系障碍研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其特征是社会沟通缺陷和重复性行为.
- 甲状腺激素在大脑发育和功能中起着至关重要的作用.
- 甲状腺激素和ASD症状严重程度之间的关系需要进一步调查.
研究的目的:
- 评估被诊断患有ASD的儿童的产后甲状腺激素水平.
- 探索血清甲状腺刺激激素 (s-TSH),自由三甲状腺素 (s-fT3) 和自由甲状腺素 (s-fT4) 水平与ASD症状的严重程度之间的关联.
- 为了确定甲状腺激素度和特定的ASD特征之间的潜在联系.
主要方法:
- 一组56名患有自闭症儿童 (24-42个月) 接受了自闭症诊断观察表第二版 (ADOS-2) 和自闭症诊断面试修订版 (ADI-R) 的诊断评估.
- 在诊断后测量了s-TSH,s-fT3和s-fT4的血清水平.
- 使用线性回归分析来检查激素水平与ASD症状严重程度之间的相关性.
主要成果:
- 几乎所有参与者的甲状腺激素水平都处于正常范围内.
- s-TSH的下降与社会互动和沟通障碍的严重程度增加 (通过ADI-R进行家长评估) 和刻板印象行为更高的患病率 (通过ADOS-2观察到) 显著相关.
- 较低的s-fT3水平与更高的刻板印象行为频率相关 (通过ADI-R对家长进行评分).
结论:
- 尽管甲状腺激素总体水平正常,但甲状腺激素度与ASD症状严重程度之间发现了特定的关联.
- 较低的TSH和ft3水平可能与ASD幼儿更明显的社会,沟通和行为挑战有关.
- 这些发现表明甲状腺激素调节在ASD症状的表现中可能发挥作用.
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