暴露于四次性化合物会通过改变内分泌信号传导和性子生成引起不孕症
Zachary A Kirkpatrick1, Vanessa E Melin1, Terry C Hrubec2
1VA-MD Regional College of Veterinary Medicine, VA Tech, Blacksburg, VA 24061, USA.
Reproductive toxicology (Elmsford, N.Y.)
|December 9, 2024
概括
口服接触四级化合物 (QACs) 通过改变激素水平和损害塞尔托利细胞功能来破坏男性和女性生殖系统,可能导致不孕.
科学领域:
- 生殖毒理学 生殖毒理学
- 内分泌学 在内分泌学.
- 环境健康 环境健康
背景情况:
- 四级化合物 (QAC) 在消费品中广泛使用.
- 以前的研究表明,QACs可以在小鼠中引起不孕症.
- 质量控制诱导不孕症背后的机制需要进一步研究.
研究的目的:
- 研究口服QAC暴露对男性和女性生殖生理学和内分泌功能的影响.
- 为了确定QAC是否会通过内分泌干扰或直接的雌同体毒性引起不育.
- 评估QACs对塞尔托利细胞恒温和精子生成的影响.
主要方法:
- 在怀孕和哺乳期间,口服QAC给小鼠.
- 测量黄素激素 (LH),卵泡刺激激素 (FSH),雌激素和孕水平.
- 试管婴儿试验测试,以评估精子的功能.
- 评估塞尔托利细胞代谢,细胞循环进展和血液-丸屏障 (BTB) 透性.
主要成果:
- 暴露在QAC下降了LH,FSH,雌激素和孕激素度.
- 在QAC度低于BTB干扰时,塞尔托利细胞代谢显著降低.
- 经过10天的休息期,精子生成受损,但暴露后并非立即发生.
- 在塞尔托利细胞中,QACs诱导了G2/M细胞周期停止.
结论:
- 口服QAC暴露会通过内分泌干扰和受损的塞尔托利细胞功能对男性和女性的生殖产生负面影响.
- QACs破坏精子生成,而不是直接引起精子毒性.
- 这些发现引起了人们对人类生殖健康的担忧,因为广泛的QAC暴露.
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