实际剂量的沉积模拟在患者特定的气道中,具有双向和四向合
Josh Williams1, Jose Manuel Menendez Montes2, Steve Cunningham3
1School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; STFC Hartree Centre, Daresbury Laboratory, Warrington, UK.
International journal of pharmaceutics
|December 9, 2024
概括
精确的吸入器模拟需要考虑粒子动量转移 (双向合) 和粒子对粒子相互作用 (四向合). 这提高了对上呼吸道药物沉积的预测,这对于优化吸入疗法至关重要.
科学领域:
- 流体动力学 流体动力学
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 吸入器释放了数百万颗药物颗粒,在呼吸道中沉积了大量物质.
- 当前的模型经常使用单向合,忽视粒子动量对空气流动的影响,可能导致不准确的沉积预测.
- 优化吸入药物输送需要更深入地了解粒子-液体和粒子-粒子相互作用.
研究的目的:
- 研究双向和四向合对患者特定气道几何形状中药物颗粒沉积的影响.
- 评估跟踪粒子组 ("粒子") 的计算效率,以模拟现实的粒子负载.
- 为了确定颗粒大小和剂量对沉积模式的影响.
主要方法:
- 在患者特定的上呼吸道模型中模拟现实的粒子数量 (高达1.6亿).
- 对比单向合 (忽略粒子动量效应) 与双向合 (包括动量转移) 和四向合 (包括粒子与粒子相互作用).
- 采用粒子建模来降低模拟各种粒子大小 (4-20μm) 的计算成本.
主要成果:
- 与单向合相比,双向合显著增加了10μm颗粒的上呼吸道沉积分数,从0.33增加到0.87.
- 在100μg剂量下,四向合可将上呼吸道沉积量减少约10%,约为100μg.
- 颗粒建模证明了不同颗粒大小的双向合的实质性影响.
结论:
- 精确模拟吸入药物沉积需要结合双向和潜在的四向合.
- 颗粒建模为研究具有复杂合效应的粒子沉积提供了一种计算效率高的方法.
- 这些发现强调了需要现实的剂量建模,以告知吸入治疗的临床决策.
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