形成水凝的微阵列贴片与基于粉末的容器相结合,用于通过皮肤传递的labetalol化
Qonita Kurnia Anjani1, Usanee Detamornrat1, Eneko Larrañeta1
1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.
International journal of pharmaceutics
|December 9, 2024
概括
这项研究引入了新的基于粉末的水库,配有水凝微阵列贴片,用于通过皮肤输送Labetalol化水. 这种系统提供了比平板药物更好的输送,用于在怀孕期间管理高血压.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 孕期高血压是一种常见的疾病,具有严重的孕产妇和胎儿风险.
- 目前口服和静脉注射Labetalol的使用带来了管理方面的挑战.
- 需要创新的药物输送方法来治疗妊娠高血压.
研究的目的:
- 开发和评估一种基于粉末的新型储系统,配有形成水凝的微阵列补丁 (MAPs),用于通过皮肤输送Labetalol化物.
- 评估MAP的机械性能和皮肤透能力.
- 为了比较新系统在体外通过皮肤传递的疗效与直接压缩的片.
主要方法:
- 制造3D打印的聚乙烯容器用于labetalol化粉和凝形成的MAP.
- 在Parafilm®和新生猪皮肤中对MAP插入的评估.
- 在体外通过皮肤递送的研究中,使用弗朗茨细胞与皮肤脱皮的新生猪皮肤.
- 两种水凝配方的比较:聚乙醇/聚乙烯酸/酸和Gantrez® S-97/聚乙烯糖醇.
主要成果:
- 这种新的系统证明了有效地插入皮肤层,针伤害最小.
- 基于粉末的储系统成功地在体外24小时内输送了labetalol化.
- 在24小时内,与Gantrez® S-97/poly (乙烯基甘醇) MAP (5 mg) 相比,Poly (乙烯基醇) /Poly (乙烯基醇) /酸MAP的药物输送量 (9 mg) 较高.
- 这种新型系统提供了比直接压缩的片更有效的labetalol化物.
结论:
- 开发的以粉末为基础的储存器与形成水凝的MAPs相结合,是通过皮肤输送Labetalol化水的有希望的方法.
- 与传统的剂量形式相比,这种系统提供了更好的输送效率.
- 对于临床使用的一步应用系统,需要进一步优化.
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