潜在不合适的药物与老年人死亡风险之间的关联:系统性审查和元分析
Yue Zhou1, YuFan Pan1, Yi Xiao1
1College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Journal of the American Medical Directors Association
|December 9, 2024
概括
潜在不合适的药物 (PIM) 使用与老年人死亡风险增加有关. 这次系统性审查和元分析发现了显著的关联,强调需要对这一群体进行仔细的药物评估.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 潜在不适当的药物 (PIM) 使用是老年人的一个重大问题,可能导致不良健康结果.
- 评估PIM与死亡风险之间的关联对于改善老年护理和药物管理至关重要.
研究的目的:
- 进行全面的系统审查和元分析,以评估PIM使用与60岁及以上个体的死亡风险之间的关系.
主要方法:
- 在多个数据库 (PubMed,Web of Science,Embase等) 中进行系统搜索. 在2024年7月23日之前进行.
- 包括的研究重点是PIM与老年人死亡风险之间的关联.
- 使用随机效应模型将效应大小结合起来,系统地探索异质性.
主要成果:
- 分析包括了44项研究,涉及超过210万名参与者,显示PIM总体发病率为45.7%.
- 在PIM使用和死亡风险增加之间发现了显著的关联 (OR, 1.28).
- 抗精神病药物 (OR,2.19) 和抗胆固醇药物 (OR,1.52) 等特定药物类显示出更高的风险,在亚洲/大洋洲和70岁以上的个体中观察到更强烈的关联.
结论:
- 这项研究证实了PIM与老年人死亡率之间的重要联系,强调了合理使用药物的重要性.
- 临床医生必须仔细评估老年患者的药物治疗方案,以减轻风险.
- 未来的研究应该完善评估工具并探索PIM对健康结果的影响,以加强药物管理策略.
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