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达凯胡 (Dachaihu) 蒸治疗败血症的有效性和安全性:一项随机对照试验
Na Huang1, Yat Hoi Tam2, Zhitong Zhang3
1The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan, 528000, China.
概括
达开 (Dachaihu decoction,简称DCH) 通过改善器官功能和减少炎症,有效治疗败血症引起的多器官功能障碍综合征 (MODS). 虽然不影响死亡率,但DCH为败血症管理提供了安全和有前途的治疗选择.
科学领域:
- 关键护理医学 关键护理医学
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
背景情况:
- 败血症是一种危及生命的疾病,导致多器官功能障碍综合征 (MODS),具有重大治疗挑战.
- 传统中国医学 (TCM),特别是达开 (DCH),在治疗败血症并发症方面表现有前途.
研究的目的:
- 在治疗败血症患者中对达开 (Dachaihu decoction,DCH) 的疗效和安全进行全面评估.
主要方法:
- 一项随机对照试验,涉及70名被分配到DCH或对照组的败血症患者.
- 干预持续时间为3天,主要结局包括28天死亡率,SOFA和APACHE II分数.
- 二次结局评估了炎症标志物,肝脏和功能,胃肠道指标和凝血参数.
主要成果:
- DCH显著降低了顺序性器官衰竭评估 (SOFA) 和急性生理和慢性健康评估II (APACHE II) 的得分.
- 肝功能,胃肠道损伤和凝血有所改善,素水平增加.
- 在28天死亡率上没有发现显著差异,但DCH组报告的严重不良事件较少.
结论:
- 达凯胡 (Dachaihu decoction,简称DCH) 在治疗败血症引起的多器官功能障碍综合征 (MODS) 方面表现出有效性和安全性.
- 建议进行进一步的研究,以优化研究设计,并改善DCH治疗的败血症患者的治疗结果.
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