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相关概念视频

Accessory Structures of the Eye01:17

Accessory Structures of the Eye

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Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Anatomy of the Eyeball01:20

Anatomy of the Eyeball

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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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相关实验视频

Updated: Jun 5, 2025

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva
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眼睛免疫系统的演变

John V Forrester1, Paul G McMenamin2

  • 1University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK. j.forrester@abdn.ac.uk.

Eye (London, England)
|December 9, 2024
PubMed
概括

眼睛免疫系统与更广泛的免疫系统一起进化,单细胞生物的原始反应和脊椎动物的适应性免疫出现. 眼睛的眼睛的眼睛的眼睛.

科学领域:

  • 进化免疫学的进化免疫学
  • 眼睛免疫学 眼睛免疫学
  • 主体-微生物相互作用

背景情况:

  • 免疫系统进化的痕迹来自早期生物中的原始抗微生物和细胞化.
  • 先天性免疫在25亿年前出现;具有抗原特异性的适应性免疫在5亿年前在脊椎动物中出现.
  • 发现B细胞和T细胞解决了关于细胞与幽默免疫的争论.

研究的目的:

  • 在生物体和免疫系统进化的更广泛框架内,将眼睛免疫系统的进化置于背景中.
  • 重新评估眼部免疫特权的概念,将其视为可变的组织特异性反应,而不是独特的现象.

主要方法:

  • 历史实验背景的审查导致免疫特权的概念.
  • 在多细胞生物体中对不同组织类型的免疫反应进行比较分析.
  • 整合现代对微生物组和全生物体概念的理解.

主要成果:

  • 免疫系统的功能就像一个恒温感应器,受到共生微生物基因 (holobiont) 的影响.
  • 组织特异性免疫反应有所不同,屏障组织 (皮肤,肠道) 表现出强烈的反应,眼睛/大脑表现出减弱的反应.
  • 眼睛免疫反应被提出作为可变组织适应免疫挑战的一个例子.

更多相关视频

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

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相关实验视频

Last Updated: Jun 5, 2025

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07:35

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

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结论:

  • 眼睛免疫系统的反应不是独一无二的,而是代表了一系列组织特异性的适应.
  • 了解免疫特权需要考虑进化背景和不同组织的可变反应.
  • 免疫系统的作用超越了对病原体的防御,到感知和维持组织平衡.