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在逆境的威胁下寻找:评估老鼠对奖励追求的控制

Sofie van Koppen^1,2, A Maryse Minnaard^1,3, Johanna A S Smeets^1,3

¹Department of Population Health Sciences, Unit of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Psychopharmacology

|December 9, 2024

概括

一个新的老鼠模型,在逆境的威胁下寻找 (STA) 任务,通过模拟不可预测的负面后果来评估物质使用障碍. 该模型显示,与糖相比,对寻求酒精和可卡因的控制减少,有助于成研究.

科学领域:

神经科学是一个神经科学.
行为药理学行为药理学
成研究研究成研究

背景情况:

药物使用障碍 (SUD) 是一种慢性复发性脑部疾病,其特征是失去对物质摄入的控制.
使用惩罚的动物模型对于研究尽管负面后果持续使用物质至关重要,有助于转化为人类SUD.

研究的目的:

在老鼠中引入寻求在逆境威胁下 (STA) 任务,结合暗示,概率和响应条件的惩罚.
模拟经常与人类上行为相关的不可预测的负面后果.

主要方法:

训练老鼠以杆压力获得糖糖,酒精或可卡因奖励.
在STA任务中,在寻求奖励时需要发出警告声,然后对回应者进行概率足震惩罚.
确定了最佳冲击强度,评估了反应稳定性和对寻找的控制丧失,并将它们与不同物质进行了比较.

主要成果:

在0.25和0.35mA之间的冲击强度适度抑制了对砂糖和酒精的反应.
反应抑制在重复测试期间保持稳定.
在STA任务中,与寻找糖相比,老鼠对寻找酒精和可卡因的控制较弱.

结论:

该STA任务有效地模拟了应对应急和不可预测的逆境,这是人类物质使用的关键方面,尽管存在负面后果.
这种新的行为范式为推进对物质使用障碍心理病理学的理解提供了宝贵的工具.

关键词:

逆境的发生逆境的发生酒精饮料酒精饮料酒精饮料酒精饮料这是可卡因可卡因.惩罚惩罚这是惩罚.它们是老鼠,老鼠,老鼠.药物使用障碍物使用障碍物糖果糖是什么糖果糖是什么

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