临床特征,放射学发现和预后的微观多炎与间歇性肺病:一个回顾性匹配对照研究
Qingzhong Song1, Yajuan Liu1, Tingting Wu2
1Department of Respiratory, Ningbo Zhenhai People's Hospital (Ningbo No. 7 Hospital), No. 718, Nan'er West Road, Luotuo Street, Zhenhai, Ningbo, Zhejiang, China.
带有间歇性肺病 (MPA-ILD) 的微观多炎比以前认为的更常见,预后更差. 对于ILD患者来说,ANCA测试至关重要,因为MPA-ILD显示出明显的成像特征和降低的生存率.
科学领域:
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 人们越来越认识到间歇性肺病 (ILD) 和微观多炎 (MPA) 之间的关联.
- 没有研究比较了MPA-ILD和ANCA阴性ILD之间的临床特征和预后.
研究的目的:
- 分析MPA-ILD和ANCA阴性ILD患者之间的临床特征和生存差异.
- 为了确定MPA-ILD的潜在成像生物标志物.
主要方法:
- 60名MPA-ILD患者和60名匹配ANCA阴性ILD患者的回顾性审查.
- 基线临床信息,实验室参数和胸部HRCT数据的分析.
- 生存分析比较两个组之间的结果.
主要成果:
- MPA-ILD患者年龄较大,CRP,ESR和血清肌素较高,血红蛋白较低.
- 在MPA-ILD中,UIP模式和奇怪形状的囊更常见.
- 与ANCA阴性ILD患者相比,MPA-ILD患者的存活时间明显较短.
结论:
- MPA-ILD并不罕见,在ILD患者中需要ANCA测试.
- 有着UIP模式的奇怪形状囊可能表明MPA-ILD.
- 老年MPA-ILD患者的预后不好,特别是那些患有扩散性膜出血 (DAH) 或急性恶化 (AEs) 患者.
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