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起草一个蓝图,设计成功的临床试验在克隆性血液形成

Shyam A Patel1, Lachelle D Weeks2

  • 1Department of Medicine-Division of Hematology/Oncology, Center for Clinical and Translational Science, UMass Chan Medical School, Worcester, Massachusetts, USA.

British journal of haematology
|December 9, 2024
PubMed
概括

设计克隆性血液形成的临床试验需要个性化的遗传风险评估,以防止骨髓瘤瘤的进展. 战略终点选择和均衡的干预措施对于有效的治疗开发至关重要.

关键词:
克隆性血液形成 (clonal hematopoiesis) 是一种细胞形成的过程.骨髓状瘤发生病.显露的骨髓状瘤瘤.

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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