在激素替代疗法周期中,在冷保存胚胎移植之前,孕激素的最佳持续时间:一项前性试点研究
Lijuan Zhao1,2,3, Liu Liu1,2,3, Yongdong Dai1,2
1Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Medicine
|December 10, 2024
概括
在冷胚胎移植 (FET) 之前的3天孕激素疗法显著改善了与4天疗法相比的怀孕和植入率. 这表明优化胚胎-子宫内膜同步,以获得更好的荷尔蒙替代疗法 (HRT) 周期的最佳结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 胚胎学 胚胎学
- 不孕症治疗 不孕症治疗
背景情况:
- 在激素替代疗法 (HRT) 周期中,最佳的孕激素补充时间对于冷胚胎移植 (FET) 成功至关重要.
- 了解子宫内膜受体性标志物有助于定时胚胎移植.
研究的目的:
- 在HRT周期中确定FET前孕激素补充的最佳持续时间.
- 评估孕激素引入持续时间对怀孕和植入率的影响.
主要方法:
- 潜在的试点队列研究,其中有127名参与者分为两个队列.
- 队列1:在模拟HRT周期中评估了从P+3到P+7的子宫内膜接受度标志物 (整体素alphavbeta3,HOXA10,LIF).
- 队列2:在经过3或4天的孕激素后,D3胚胎移植后的监测妊娠结果.
主要成果:
- 生物化学怀孕率在3天孕激素组 (87.18%) 与4天组 (68.42%) 相比,在3天孕激素组更高.
- 胚胎植入率在3天组 (74.36%) 与4天组 (65.79%) 相比,在3天组显著提高.
- 在HRT周期中,在P+6日左右观察到子宫内膜受体性标记的峰值.
结论:
- 在D3胚胎移植前3天的孕激素补充方案可以优化胚胎-子宫内膜同步.
- 这种较短的孕激素引入期显示出在FET周期中改善临床结果的潜力.
- 这些发现表明,HRT-FET协议的最佳孕激素持续时间可能会发生转变.
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