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CD146+内皮细胞通过内皮转移到介质细胞转移促进间纤维化

Huixian Zhang¹, Liling Zhang^1,2, Dongli Tian¹

¹Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Annals of transplantation

|December 10, 2024

概括

在脏间歇性纤维化 (RIF) 时,内皮细胞上的CD146表达增加. 这些CD146阳性细胞经历了内皮-介质酶过渡 (EndMT),可能是由PDGF-B/PDGFR-β通路驱动的,有助于RIF.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
细胞生物学细胞生物学
病理学病理学病理学

背景情况:

内皮细胞与间纤维化 (RIF) 病原发生有关.
CD146在受伤的内皮细胞上升调节,但其在RIF中的作用尚未完全理解.

研究的目的:

调查RIF中CD146表达和内皮细胞之间的关联.
探索CD146在促进RIF中的内皮-介质细胞过渡 (EndMT) 中的作用和机制.

主要方法:

在慢性病患者和单侧尿道阻塞 (UUO) 鼠标模型中使用双标签和多重免疫光染色.
为了评估RIF的严重程度,采用了血素和素和马森三色染色.

主要成果:

增加的CD146+内皮细胞与患者和小鼠的RIF严重程度正相关.
在严重的RIF中观察到CD146+EndMT细胞的增加.
PDGF-B/PDGFR-ß信号通路组件与CD146+CD31+α-SMA+细胞共局部,表明该通路参与.

结论:

在RIF期间,CD146主要表达在脏间歇性血管内皮细胞上.
CD146参与RIF中的EndMT,可能涉及PDGF-B/PDGFR-ß信号通路.

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