植物性雌激素作为天然抗衰老解决方案,用于增强皮肤中的原蛋白合成
Nahid Amini1, Christina Osterlund1, Jessen Curpen1
1Global Research and Development, Oriflame Cosmetics, Stockholm, Sweden.
Journal of cosmetic dermatology
|December 10, 2024
概括
草甘 (Glycyrrhiza uralensis) 提取物可以提高原蛋白的产生和皮肤密度. 这种天然的植物雌激素可以通过增加原蛋白和抑制MMP1.1,改善绝经后妇女的皮肤健康.
科学领域:
- 皮肤病学 皮肤病学
- 自然产品化学 自然产品化学
- 生物化学 生物化学
背景情况:
- 皮肤的细胞外基质 (ECM) 依赖于原来获得结构和弹性.
- 绝经后雌激素下降显著减少原蛋白 (I型和III型) 在5年内高达30%.
研究的目的:
- 为了确定刺激原蛋白合成的天然提取物.
- 为了评估格莱西瑞莎乌拉伦西斯 (Glycyrrhiza uralensis) 提取物改善皮肤健康的疗效.
主要方法:
- 使用PathwayStudio分析蛋白质相互作用并确定原调节剂.
- 在体外研究中评估了G. uralensis提取物对人类皮肤纤维细胞的作用.
- 在体内研究中评估了一种含有G. uralensis提取物的局部配方,用于皮肤密度.
主要成果:
- 植物性雌激素,如G. uralensis中的liquiritigenin被确定为潜在的原体增强剂.
- G. uralensis提取物增加了原I和III基因表达和前原I蛋白.
- 提取物抑制了UVB和污染诱导的矩阵金属蛋白酶-1 (MMP1) 生产.
- 在G. uralensis提取物的局部应用在体内显著改善了皮肤密度.
结论:
- G. uralensis 提取物显示出增强原蛋白生产和皮肤健康的潜力.
- 提取物对于治疗绝经后妇女皮肤衰老特别有希望.
- 需要进一步的研究来阐明提取物的机制和长期影响.
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