在患有MAFLD的2型糖尿病患者中,血管内皮功能和骨矿物密度之间的相关性
Peiyan Du1,2, Jianxiang Jiang1,2, Yurong Liu1,2
1Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Acta cardiologica
|December 10, 2024
概括
在患有脂肪肝的2型糖尿病患者中,血管内皮功能减弱 (FMD<4%) 与较低的骨矿物密度 (BMD) 和较高的骨折风险有关,特别是在女性中. 这表明 FMD 是 FMD.
科学领域:
- 内分泌学和新陈代谢学
- 心血管健康 心血管健康
- 骨健康和骨质疏松症
背景情况:
- 在2型糖尿病 (T2DM) 和代谢功能障碍相关的脂肪肝 (MAFLD) 患者中,血管内皮功能和骨矿物密度 (BMD) 之间的相互作用仍然不太清楚.
- 评估血管内皮功能和骨健康对于管理患有MAFLD的T2DM患者至关重要,因为他们患心血管和骨并发症的风险增加.
研究的目的:
- 调查通过流媒扩张 (FMD) 测量的血管内皮功能与在被诊断为MAFLD的T2DM患者中的BMD或骨折风险之间的相关性.
- 探索不同水平的口病如何影响这个特定患者队列中的骨损伤和骨折风险.
主要方法:
- 一组872名50岁及以上的T2DM患者被分为MAFLD阳性 (MAFLD+) 和MAFLD阴性 (MAFLD-) 组.
- 通过高分辨率超声波使用流介导扩张 (FMD) 来评估血管内皮功能.
- 使用双能X射线骨密度计测量骨矿物质密度 (BMD),并使用FRAX评分计算10年骨折风险 (部和主要骨质疏松症).
主要成果:
- 在多变量调整后,在MAFLD阴性组中没有观察到口和骨疾病之间的显著相关性.
- 在患有口腔炎<4%的MAFLD阳性患者中,发现口腔炎和骨质炎 (全身,腰椎,大腿部) 之间存在正相关性,以及骨折风险和骨质疏松性骨折史的负相关性,特别是在女性中.
- 在4-7%或7%以上的口水平的MAFLD阳性患者中,没有检测到口和骨疾病或骨折风险之间的相关性.
结论:
- 在患有MAFLD的T2DM患者中,口疾病和骨疾病之间的关联取决于口疾病水平.
- 减少的口病 (<4%) 与减少的骨和增加的骨折风险有关,女性T2DM患者有MAFLD.
- 口病可能在骨质疏松症的发展中发挥重要作用,并且在患有MAFLD的T2DM患者中对早期骨质疏松症诊断具有潜在的临床价值.
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