与常规护理相比,使用高血压标准化治疗方案的有效性和安全性:随机临床试验的元分析
Gautam Satheesh1, Rupasvi Dhurjati1, Vivekanand Jha2,3,4
1The George Institute for Global Health, Hyderabad, Telangana, India.
Journal of clinical hypertension (Greenwich, Conn.)
|December 10, 2024
概括
与常规护理相比,标准化治疗方案 (STP) 显著降低血压,改善高血压控制. 本次审查强调了STP作为管理全球高血压负担的有效策略.
科学领域:
- 心血管医学 心血管医学
- 公共卫生 公共卫生
- 基于证据的实践.
背景情况:
- 全球高血压的诊断,意识,治疗和控制面临着重大挑战.
- 建议制定标准化治疗方案 (STP),以指导高血压管理,特别是在初级保健中.
- 缺乏对STPs对降低和控制血压的影响的定量审查.
研究的目的:
- 系统地审查和元分析随机临床试验 (RCT),评估高血压STPs对降低和控制血压 (BP) 的影响.
- 为了比较STPs与高血压管理中的常规护理的疗效.
主要方法:
- 对RCT进行系统审查和随机效应的元分析.
- 包括16个RCT,59,945名患有高血压的成年参与者.
- 主要结局:静脉血压降低;次要结局:静脉血压降低,血压控制和不良事件.
主要成果:
- 与通常的护理相比,STPs导致静脉血压 (6.7 mmHg) 和静脉血压 (2.6 mmHg) 的显著降低 (p < 0.001).
- 血压控制率与STPs (57%) 相比,通常护理 (24%) 的血压控制率要高得多 (p < 0.001).
- 在STP和常规护理之间,不良事件的总体发生率没有显著差异.
结论:
- 高血压 STPs显著降低缩和腹缩血压,并改善血压控制.
- STPs代表了实施基于证据的高血压治疗的有效策略.
- 这些协议可以帮助提高治疗覆盖率,以应对未经治疗和不受控制的高血压的全球负担.
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