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Updated: Jun 5, 2025

An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector
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Published on: January 12, 2018

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睡眠美女转体酶的一种新型过活变体促进了非病毒基因组工程

Matthias Thomas Ochmann1, Csaba Miskey1, Lacramioara Botezatu1

  • 1Research Center, Division of Hematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.

Molecular therapy. Nucleic acids
|December 10, 2024
PubMed
概括

研究人员开发了一种过度活跃的睡眠美女 (SB) 转移酶变体,SB200X,显示基因转移效率提高. 这种增强的SB转子子系统为潜在的基因治疗应用提供了改进的基因组工程.

关键词:
结合 DNA 的 DNA 结合.DNA与蛋白质的相互作用MT:RNA/DNA编辑 编辑基因插入 基因插入基因转移是转移基因的过程.造血干细胞是造血干细胞的组成部分.诱导的多能干细胞干细胞.非病毒基因组工程非病毒基因组工程转换酶可以转换.转换一个转换器.转换法规中的规定.

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