在中度至重度的COVID-19中醒着易感定位的有效性随机对照试验
Nguyen Thanh Phong1, Du Hong Duc2, Ho Bich Hai2
1Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Wellcome open research
|December 10, 2024
概括
醒着易感定位 (APP) 没有改善COVID-19患者的呼吸支升级. 虽然安全,但实现足够的APP持续时间是具有挑战性的,患者更喜欢躺卧的位置.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 清醒的倾向性定位 (APP) 是一种潜在的干预措施,用于非机械通风的呼吸衰竭患者.
- 之前对APP的试验是在未接种疫苗的人群中在COVID-19的高峰期进行的,对患者的遵从性和可接受性的数据有限.
- 这项研究评估了APP在中低收入国家中的有效性和可接受性.
研究的目的:
- 评估住院COVID-19患者的清醒倾向定位 (APP) 的有效性和患者接受度.
- 为了确定APP是否减少了升级呼吸辅助的需要.
- 探索使用可穿戴连续监控设备用于APP评估的可行性.
主要方法:
- 在越南进行了一项开放标签,随机对照试验.
- 接受补充氧气的中度至重度COVID-19的成年患者被随机分配到标准护理或具有专门支持团队的APP.
- 可穿戴设备持续监测脉冲氧计和身体位置;主要结果是28天内呼吸支的升级.
主要成果:
- 86%的患者已经接种了疫苗.
- 虽然分配给APP的患者每天的定位时间更长,但大多数患者没有达到8小时的目标.
- 两组之间在呼吸支升级,输管率或28天死亡率方面没有发现显著差异. 患者发现倾斜的位置舒适,但更喜欢躺着.
- 没有报告任何不良事件.
结论:
- 在这种环境中,醒着易感定位 (APP) 在减少COVID-19患者的呼吸支升级方面没有显著的益处.
- 使用可穿戴设备进行持续监控是可行的和可以接受的.
- 实现延长APP持续时间证明具有挑战性,患者偏好倾向于仰卧.
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