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平行运动通路的补偿性适应促进了经过脊髓损伤后熟练的前肢恢复

Imran S Sheikh¹, Kathleen M Keefe¹, Noelle A Sterling¹

¹Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

|December 10, 2024

概括

康复性训练通过增强自身脊髓内神经元 (PNs) 和脊髓神经元 (RNs) 来帮助皮质脊髓管 (CST) 损伤后前肢功能恢复. 在恢复后沉默这些通路会损害功能,突出显示它们的并行作用.

科学领域:

神经科学是一个神经科学.
发动机控制器发动机控制器
脊髓损伤研究研究脊髓损伤研究

背景情况:

熟练的前肢运动取决于皮质脊髓管 (CST) 和脑干路径.
中枢神经系统病变会损害前肢功能,但康复可以通过间接途径促进恢复.
脊髓损伤 (SCI) 研究探讨了用于功能恢复的脊柱上自身脊柱电路的可塑性.

研究的目的:

研究椎自身脊髓内神经元 (PNs) 和脊椎神经元 (RNs) 在中枢神经系统和背脊损伤后的运动恢复中的作用.
确定PN和RN对大鼠达到和掌握行为所做出的贡献.
评估安静PN或RN对恢复前肢功能的影响.

主要方法:

在老鼠的CST和背脊柱的C5的双边病变.
对取回颗粒的行为评估,以量化达到和抓取能力.
通过使用特定技术将PN或RN沉默来进行恢复后的功能评估.
组织学分析以检查CST纤维在脊髓和红核中发芽的情况.

主要成果:

双边的CST和背脊损伤导致颗粒检索有50%的缺陷.
四周的康复训练使颗粒提取性能正常化.
恢复后的PN或RN的沉默单独降低了检索成功.
同时对PN和RN进行沉默导致了显著的功能损失,表明了并行贡献.
在脊髓和红核中观察到CST纤维生长的证据.

结论:

宫自身脊髓内神经元 (PNs) 和脊椎神经元 (RNs) 在CST损伤后恢复熟练前肢功能的过程中发挥着至关重要的并行作用.
康复性培训增强了这些间接途径对运动控制的贡献.
针对PN和RN可能提供治疗策略,以改善脊髓损伤后的运动功能.

关键词:

生物科学生物科学自然科学自然科学神经科学是一个神经科学.系统神经科学系统神经科学

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