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性酸酶与严重白质过强度患者的血管抑郁有关

Xi Tao^1,2,3, Yuqi Yin¹, Yi Zhang¹

¹Department of Neurological Rehabilitation, Hunan Provincial People's Hospital, Hunan Normal University, Changsha, Hunan, China.

Frontiers in neuroscience

|December 10, 2024

概括

性酸酶 (ALP) 的升高与严重白质超强度 (sWMHs) 患者的血管抑郁 (VDe) 有关. 将ALP与其他标记物结合起来,可以在轻度和重度WMH组中改善VDe诊断.

科学领域:

神经学神经学
生物化学生物化学
精神病学是一个精神病学.

背景情况:

脑血管疾病 (CVD) 是抑郁症的一个重要风险因素.
高酸酶 (ALP) 预测了绝经前妇女的脑血管事件和抑郁症.
在患有白质超强度 (WMHs) 的患者中,高ALP和血管抑郁 (VDe) 之间的联系尚不清楚.

研究的目的:

在WMHs患者中研究ALP水平升高与VDe之间的关联.
评估组合血清标志物在WMH子组内检测VDe的诊断疗效.

主要方法:

一项横截面研究包括265名心血管疾病患者,根据Fazekas分数分类为轻度 (mWMHs) 和严重 (sWMHs).
收集了人口统计,血液和MRI数据;进行了单变量和逻辑回归分析.
对VDE多变量模型的诊断有效性使用二进制和顺序逻辑回归进行了评估.

主要成果:

ALP和过敏性C反应蛋白 (hs-CRP) 在不同抑郁症得分的mWMHs和sWMHs组中表现不同.
结合标记物 (ALP与阿波利波蛋白A1或血红蛋白) 在sWMH (AUC=0.849) 和mWMH (AUC=0.718) 患者中提高了VDE诊断效率.
在sWMH患者中,血清ALP与VDe独立相关 (OR=1.016).

结论:

结合多个生物标志物可以提高VD诊断的准确性,特别是当被WMH严重程度分层时.
血清ALP是严重WMHs患者中VDe的显著预测因素.

关键词:

性酸酶是一种性性酸酶.协会协会协会协会协会脑血管疾病脑血管疾病血管抑郁症是一种血管抑郁症.白质的超强度是白质的超强度.

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