中性粒细胞细胞外陷髓氧化酶和弹性酶预测动脉瘤下arachnoid出血后大脑血管
Saba Sajjad1, Michael Hewera2, Majeed Rana1
1Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Düsseldorf, Germany.
Heliyon
|December 10, 2024
概括
中性粒细胞外细胞陷 (NETs) 的组成部分,特别是骨髓氧化酶 (MPO) 和弹性酶 (ELA),可以预测动脉瘤下关节出血 (aSAH) 后的大脑血管 (CVS). 结合MPO和ELA水平可以改善aSAH患者CVS的早期预测.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 动脉瘤下关节出血 (aSAH) 是一种严重的疾病,死亡率和发病率很高.
- 脑血管 (CVS) 等aSAH后并发症显著影响患者的治疗结果.
- 需要准确的诊断生物标志物来预测这些并发症.
研究的目的:
- 为了研究中性粒细胞外细胞陷 (NETs) 组件在aSAH之后对CVS的预测价值.
- 评估血清中髓氧化酶 (MPO),弹性酶 (ELA) 和素化基因素H3 (cH3) 的水平,作为潜在的生物标志物.
- 评估这些生物标志物在aSAH早期预测和管理中的实用性.
主要方法:
- 前性探索性研究包括62名aSAH患者,17名未破裂动脉瘤患者和12名健康对照.
- 使用ELISA测量MPO,ELA和cH3的血清水平,在治疗后的第1天和第4天测量.
- 统计分析包括Yeo-Johnson转换,t测试,ANOVA,以及对模型CVS预测的后勤回归.
主要成果:
- 与未破裂动脉瘤患者相比,aSAH患者在第一天的MPO,ELA和cH3血清水平显着更高.
- 单独来看,第一天的MPO和ELA水平在CVS和没有CVS的患者之间没有区别.
- 结合MPO和ELA水平的物流模型预测CVS具有91%的灵敏度和79%的特异性.
结论:
- NETs组件 (MPO和ELA) 参与aSAH及其并发症的病理生理学.
- 结合MPO和ELA水平作为aSAH患者中CVS的早期预测剂.
- 这些生物标志物可以指导SAH管理中的治疗决策.
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