中性粒细胞外细胞陷在克罗恩病中的作用
Ying Liu1, Heng Deng2, Jinfeng Yao3
1College of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Heliyon
|December 10, 2024
概括
中性粒细胞外细胞陷 (NETs) 通过招募免疫细胞并影响肠道屏障功能,在克罗恩病 (CD) 发病过程中发挥关键作用. 针对NETs提供了一个有希望的治疗策略,用于管理CD炎症和症状.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 克罗恩氏病 (CD) 是一种具有复杂起源的慢性胃肠道炎症状况.
- 中性粒细胞外细胞陷 (NETs) 是由中性粒细胞释放的结构,在CD病变发生过程中越来越多地被识别出来.
研究的目的:
- 审查NETs在克罗恩病病原发生中的作用.
- 探索NETs对免疫细胞招募,上皮质屏障功能和炎症的影响.
- 讨论针对CD治疗的NET治疗策略.
主要方法:
- 文献综述侧重于中性粒细胞外细胞陷 (NETs) 和克罗恩病.
- 分析NETs导致炎症和屏障功能障碍的机制.
- 检查针对NET的当前和潜在治疗干预措施.
主要成果:
- NETs参与招募免疫细胞到炎症的胃肠道组织.
- NETs可能会损害胃肠上皮屏障的完整性.
- NETs通过促炎分子释放,促进克罗恩病的炎症循环.
结论:
- NETs是克罗恩病发病的一个重要因素.
- 准NET的形成或功能为克罗恩病提供了一个可行的治疗途径.
- 对NET机制的进一步研究对于开发新的CD治疗方法至关重要.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
115
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
115
Inflammatory Bowel Disease II: Crohn's Disease
184
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
184


