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Updated: Jun 5, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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多功能T细胞和独特的细胞因子集群印记了抗rAAV2/rAAV9载体免疫反应

Stephan J Holtkamp1, Florian R Lagoda1, Adam Lister2

  • 1Drug Discovery Sciences, Bayer AG, Wuppertal, Germany.

Frontiers in immunology
|December 10, 2024
PubMed
概括

多功能T细胞对复合腺相关病毒 (rAAV) 载体具有显著的反应性,释放炎症性细胞因子. 这一发现对于推进基因治疗安全性和载体选择至关重要.

关键词:
CD4 T 细胞免疫力在T细胞分泌体内,T细胞分泌体腺相关病毒的病毒.基因治疗的基因疗法免疫性 免疫性 免疫性多功能T细胞多功能T细胞

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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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