用于组织工程应用的甲基烯酸酸盐的电
Daria Poshina1, Natalia Sokolova1, Steve Nono-Tagne2
1Institute of Macromolecular Compounds, Branch of Petersburg Nuclear Physics Institute named by B.P. Konstantinov, National Research Centre Kurchatov Institute Bolshoy pr. V.O. 31 199004 St Petersburg Russia poschin@yandex.ru.
RSC advances
|December 10, 2024
概括
甲基烯酸酸衍生物被电成均的纤维. 这些照片交叉连接的酸盐纤维显示出对多能介质干细胞 (MSC) 的良好细胞兼容性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 组织工程是组织工程.
背景情况:
- 酸是一种生物相容的多糖,具有生物医学应用的潜力.
- 开发新的酸盐衍生物对于先进的材料制造至关重要.
- 电为创建纳米纤维支架提供了一种多功能方法.
研究的目的:
- 为了合成可光交叉链接的甲基烯酸酸衍生物 (M-ALGs).
- 使用针和无针电制造非织造的M-ALG纤维.
- 评估交叉链接的M-ALG支架与间酶体干细胞 (MSC) 的细胞相容性.
主要方法:
- 甲基酸盐被用甘氨基甲基酸盐修饰,以产生M-ALGs.
- 针和无针电技术被优化为纤维生产.
- 通过紫外线辐射进行光学交叉连接,使得纤维在生理介质中不溶.
- 在交叉连接的支架上培养了介质干细胞 (MSC).
主要成果:
- 均的,没有珠子的M-ALG纤维,平均直径为150nm,已成功生产出来.
- 无针电技术可以容纳更广泛的溶液特性.
- 照片交叉连接的M-ALG纤维地毯在生理条件下保持了机械完整性和不可溶性.
- 培养的MSC在支架上形成球形殖民地,表明良好的细胞兼容性.
结论:
- 可通过光交叉链接的M-ALG可以通过电有效地制造成纳米纤维支架.
- 开发的支架具有适合细胞培养应用的特性.
- 这些M-ALG支架显示了组织工程和再生医学的前景.
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