基于纳米技术的方法在治疗头部和部状细胞癌的进展
Bicai Tang1,2,3, Rui Huang1, Wenjuan Ma1,2,3
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu Sichuan 610041 China.
RSC advances
|December 10, 2024
概括
纳米技术为头部和部状细胞癌 (HNSCC) 的治疗和诊断提供了有前途的进展. 纳米粒子增强了药物输送和向,改善了对这种具有挑战性的癌症的治疗结果.
科学领域:
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 头部和部状细胞癌 (HNSCC) 由于侵袭性和有限的治疗疗效,存在显著的死亡风险.
- 目前的手术,化疗和放射治疗等疗法都有缺点,包括耐药性和对健康组织的损伤.
- 现有的先进治疗方法,如免疫疗法,光动力疗法 (PDT) 和光热疗法 (PPT),在瘤向和治疗结果方面面临挑战.
研究的目的:
- 审查目前HNSCC的治疗和诊断策略.
- 突出纳米颗粒 (NP) 在HNSCC治疗中的特性和应用.
- 讨论基于纳米技术的HNSCC疗法的挑战和未来前景.
主要方法:
- 对有关HNSCC治疗和诊断的现有文献的审查.
- 对纳米粒子属性的分析,包括形态学和物理化学特征.
- 在药物输送,瘤向和HNSCC直接抗瘤活性方面对NP应用的调查.
主要成果:
- 纳米粒子具有独特的特性,适用于HNSCC的直接抗瘤活性和药物输送.
- 通过联结,NP可以在结构上进行修改,以增强药物递送和瘤向.
- 纳米技术为改善生物相容性和对HNSCC细胞的特定传递提供了潜力.
结论:
- 基于纳米技术的方法在优化HNSCC治疗和诊断方面显示出显著的前景.
- 对纳米粒子应用的进一步研究对于克服当前治疗限制至关重要.
- 解决临床翻译中的障碍是实现纳米技术对HNSCC患者的全部潜力的关键.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
12:03Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
19.2K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K