相关实验视频
Updated: Jun 5, 2025

08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
7.2K
骨髓瘤中自的趋势和未来方向:一个图书统计分析
JinXiang Shang1, FeiYing Zhao2, Lu Xie1
1Department of Orthopedics, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Open medicine (Warsaw, Poland)
|December 10, 2024
概括
这份图书统计分析揭示了对自在患儿骨癌骨髓瘤中的作用日益增长的研究兴趣. 未来的研究将集中在针对侵袭,迁移和细胞死亡的新型治疗策略上.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生化学
背景情况:
- 骨髓瘤是一种恶性骨瘤,主要影响儿童和青少年.
- 自是一种关键的细胞过程,与骨髓瘤病理生理学有关.
- 了解自的作用对于开发有效的骨髓瘤治疗方法至关重要.
研究的目的:
- 进行关于骨髓瘤中自的研究的文献分析.
- 识别关键趋势,有影响力的作品和新兴研究热点.
- 预测该领域未来的研究方向.
主要方法:
- 在科学网络核心集合 (2008-2024) 上进行了全面的文献搜索.
- 用VOSviewer,CiteSpace,R软件,Excel和Scimago.com进行了图书识别分析和可视化.
- 分析包括出版趋势,有影响力的作者,领先的机构,顶级期刊,高度引用的论文和关键字的共同出现.
主要成果:
- 关于骨质肉瘤自的研究表明,在过去17年中,自的数量稳步增加.
- 上海通大学的张元和*细胞死亡和疾病*分别被确定为主要作者,机构和期刊.
- 关键的研究领域包括耐药性,治疗点,自机制,基因组影响,入侵,迁移和细胞死亡.
结论:
- 本文献分析提供了关于骨髓瘤自的当前研究格局的全面概述.
- 它强调了诸如入侵,迁移和细胞死亡等关键领域,为未来的治疗开发提供了宝贵的见解.
- 这项研究可以作为研究人员的资源,旨在开发针对骨髓瘤的新疗法.
相关概念视频
Autophagy
4.2K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.2K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
The Proteasome
8.5K
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
8.5K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K

