儿童肺功能与青少年发病和持续性喘有关.
Hans Jacob L Koefoed1,2,3, Anhar Ullah4, Jenny Hallberg3,5
1University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands.
ERJ open research
|December 10, 2024
概括
在学龄时肺功能较好的儿童在青春期晚些时候患喘的风险较低. 这表明,儿童期肺功能受损可能导致喘发作和持续.
科学领域:
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 喘与肺功能减弱有关,但儿童肺功能和青少年喘之间的关系尚不清楚.
- 研究早期肺功能作为青少年喘发病和持续性的预测因素,对于了解疾病发展至关重要.
研究的目的:
- 检查儿童期肺功能与青少年期喘的发病和持续之间的关联.
- 为了确定早期的肺功能指标是否可以预测青少年未来的喘发展.
主要方法:
- 利用了来自三个基于人口的出生队列 (BAMSE,PIAMA,MAAS) 的数据,包括8岁时的分析.
- 评估1秒内强制呼吸量 (FEV1),强制生命能力 (FVC) 和FEV1/FVC比率.
- 使用后勤回归和元分析来评估与青少年喘发病和持续性的关联.
主要成果:
- 在8岁时预测的FEV1%和FEV1/FVC比率较高,与青少年发作喘的几率降低有关 (分别为0.98和0.97).
- 即使在没有先前治疗喘息或喘的儿童中,这些关联仍然很重要.
- 8岁时FEV1/FVC比率升高也与青春期持续性喘的几率较低相关 (OR 0.96).
结论:
- 更好的儿童肺功能与青少年发作喘风险降低有关,特别是在男性中.
- 儿童时期的下肺功能可能是喘发病率和持续性的前身或贡献.
- 这些发现凸显了早期肺部发育在喘轨迹中的潜在作用.
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