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在患有中度至重度阻塞性睡眠呼吸暂停的患者中,休息状态长期和短期功能连接的密度变化

Yumeng Liu¹, Huizhen Xin¹, Yongqiang Shu^1,2

¹Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.

Nature and science of sleep

|December 10, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 改变了大脑的功能连接密度 (FCD),影响了认知功能,使患者与健康人区分开来. 这些大脑变化为OSA中神经认知提供了见解.

科学领域:

神经成像是一种神经成像.
睡眠医学睡眠医学
认知神经科学认知神经科学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与认知障碍有关.
了解在OSA中认知缺陷的神经支柱至关重要.

研究的目的:

评估OSA患者的功能连接密度变化 (FCD).
调查FCD和认知功能之间的关系.
确定FCD是否可以区分OSA患者与健康对照 (HC).

主要方法:

休息状态功能磁共振成像 (fMRI) 用于76名OSA患者和72名HC患者.
对长距离和短距离连接进行了功能连接密度 (FCD) 分析.
支持矢量机 (SVM) 用于根据FCD对OSA患者和HC进行分类.

主要成果:

OSA患者在上额头 (SFG),前骨和中额头 (MFG) 的长距离FCD减少,在带状 (CG) 的FCD增加.
短距离的FCD在OSA患者的后中心 (PoCG),SFG,MFG和CG中减少.
在右侧的PoCG中减少了短程FCD,与OSA患者的认知得分相关.
通过使用FCD模式,SVM分析成功地将OSA患者与HC患者区分开来.

结论:

在OSA患者中改变的长距离和短距离FCD可能会导致认知能力下降.
FCD模式作为有效的生物标志物,可以将OSA与健康对照区分开来.
这些发现增强了我们对OSA神经认知变化的理解.

关键词:

认知功能认知功能功能连接密度的功能连接密度.功能性磁共振成像技术功能性磁共振成像技术阻塞性睡眠呼吸暂停 (SOP) 的情况.

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