抑郁症状对患有COVID-19后疾病的人的动机的影响
Juliana West1, Angela T H Kwan1,2, Kayla M Teopiz1
1Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
CNS spectrums
|December 10, 2024
概括
抑郁症状与患有COVID-19后疾病 (PCC) 的成年人的动机降低有关. 解决抑郁症可能会改善COVID-19感染后经历PCC的人的动力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19条件 (PCC) 被世界卫生组织定义为在SARS-CoV-2感染后持续的症状.
- 患有PCC的人经常报告显著的抑郁症状和动机缺陷.
- 了解这些症状之间的关系对于有效的患者管理至关重要.
研究的目的:
- 研究成年人被诊断患有PCC的抑郁症状严重程度和动机系统之间的关联.
- 分析PCC随机对照试验的基线数据.
主要方法:
- 对一项为期8周的双盲,安慰剂对照试验的数据进行了后期分析.
- 参与者包括加拿大的成年人 (≥18岁) 患有世卫组织定义的PCC和认知症状.
- 使用QIDS-SR-16评估抑郁症状,使用BIS/BAS问卷评估动机.
主要成果:
- 在抑郁症状和行为抑制系统 (BIS) 之间发现了显著的关联.
- 抑郁症也与较低的BAS奖励反应率有关,这一发现受性别和确诊的COVID-19感染的影响.
- 对于BIS (β = -0.041,p<0.05) 和BAS奖励响应 (β = 0.043,p<0.05) 观察到的统计学意义.
结论:
- 抑郁症症状与COVID-19后病情患者的动机缺陷有显著的关联.
- 针对性和优化抑郁症状的治疗可能为改善PCC患者的动机障碍提供了一条途径.
- 医疗保健提供者应考虑对患有重大抑郁症 (MDD) 和COVID-19病史的患者进行PCC评估.
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