通过和二氧化催化过氧化氧化氧化,从酒精中合成碳酸的连续流合成
Yoshihiro Kon1, Takuya Nakashima1, Yoshiki Makino2
1Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan. y-kon@aist.go.jp.
Organic & biomolecular chemistry
|December 10, 2024
概括
一种新的连续流程方法有效地将酒精氧化为碳氧酸,使用过氧化和催化剂. 这种稳定,有选择性的工艺为各种酒精提供了高产量,唯一的副产品是水.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 化学工程是化学工程的重要组成部分.
背景情况:
- 酒精直接氧化成碳酸盐酸是有机合成中的关键转化.
- 现有的方法往往受到低选择性,恶劣的条件,或形成不良的副产品,如化物.
- 连续流化学在反应控制,安全和可扩展性方面具有优势.
研究的目的:
- 开发一种连续流的方法,用于直接和选择性氧化酒精到碳酸盐酸.
- 研究用过氧化作为氧化剂与催化剂在流系统中的使用.
- 为了优化反应条件以获得高产量和选择性,最大限度地减少化物形成.
主要方法:
- 使用连续流动反应器系统,用 (Pt) 催化剂和过氧化 (H2O2) 作为氧化剂.
- 多种重量每小时空间速度 (WHSV) 控制反应剂-催化剂接触时间并优化选择性.
- 分析的产品产量 (化物与碳酸) 作为WHSV的函数.
- 使用X射线光电子谱学 (XPS) 描述了催化剂的稳定性.
主要成果:
- 从酒精中获得碳酸的选择性合成,而没有形成化物.
- 证明了Pt催化剂的高催化稳定性,从1-octanol产生25.2g的八度酸,在210小时内产生>96%的产量.
- 展示了广泛的基质范围,在19-98%的孤立产量中成功氧化了各种阿利法性,芳香性,性和异芳香性酒精到相应的碳素酸.
- 通过XPS分析证实了在反应过程中金属零价值Pt (Pt(0) 的保存.
结论:
- 开发的Pt催化连续流氧化方法对于从各种酒精中合成碳酸盐非常有效.
- 该系统可以精确控制反应参数,从而实现出色的选择性和高产量.
- 这种方法为碳酸生产提供了可持续和高效的替代方案,利用水作为唯一的副产品.
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