治疗出现的中央睡眠呼吸暂停会随着呼吸压力降低而消失
William H Noah1, Ludovico Messineo2, Bernard Hete1
1Sleep Centers of Middle Tennessee, Murfreesboro, Tennessee.
概括
治疗引起的中央睡眠呼吸暂停 (TECSA) 通过使用一种新型装置降低吸入性正气道压力 (IPAP) 得到了有效的解决. 这项研究表明,降低IPAP可以消除接受CPAP治疗的患者的中央呼吸暂停.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 治疗出现的中央睡眠呼吸暂停 (TECSA) 是阻塞性睡眠暂停的持续正气道压力 (CPAP) 治疗期间的常见并发症.
- 导致TECSA的确切机制尚未完全理解,但增加的潮体积已被涉及.
研究的目的:
- 为了评估一种旨在降低吸入性正气道压力 (IPAP) 的装置在解决TECSA时的有效性.
- 确定减少IPAP是否可以消除TECSA患者的中央呼吸暂停.
主要方法:
- 在患有TECSA的患者中,在分夜定位期间,在CPAP电路中添加了一种减少IPAP的装置.
- 在装置实施之前和之后测量了中央呼吸暂停指数.
主要成果:
- 该研究包括1613名患者,其中19人患有TECSA.
- 该设备在所有具有足够数据 (n=13) 的患者中完全消除了TECSA.
- 中心呼吸暂停指数显著下降,从17.3±11.0降至1.5±1.7事件/小时 (P<.001).
结论:
- 使用测试设备减少IPAP有效地解决了所有参与者的TECSA.
- 降低IPAP似乎是管理CPAP治疗患者中枢呼吸道事件的有希望的策略.
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