Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

846
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
846
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

12.4K
In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or...
12.4K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

748
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
748

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

momapy: a Python library to work with molecular maps.

Bioinformatics (Oxford, England)·2026
Same author

Multiomic and Longitudinal Dissection of Immune Dynamics Associated with Parkinsonism after Ciltacabtagene Autoleucel Therapy.

Blood cancer discovery·2026
Same author

MyCARdiac score: integrating cardiac imaging and biomarkers to predict outcomes in RRMM patients receiving cilta-cel.

Leukemia·2026
Same author

Anti-CD4 antibody-modulated transplants for GVHD prevention in hematopoietic cell transplantation.

Blood·2026
Same author

Systems biology graphical notation: process description language level 1 version 2.1.

Journal of integrative bioinformatics·2026
Same author

The Inflammatory Skin Disease map: an interactive computational resource focused on molecular mechanisms in psoriasis and atopic dermatitis.

The British journal of dermatology·2025

相关实验视频

Updated: Jun 5, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

使用交互式平台来编码,管理和探索与免疫相关的不良结果途径.

Alexander Mazein1, Muhammad Shoaib1, Miriam Alb2

  • 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.

Journal of immunotoxicology
|December 10, 2024
PubMed
概括

本研究引入了系统免疫毒理学工作流程,以预测免疫调节疗法的不良结果. 它整合了不良结果路径和系统医学疾病地图,以加强安全评估.

关键词:
在 AOP AOP 中.在CAR T细胞中,在CRS中,您可以使用CRS.负面结果的途径.仿制性抗原受体的复制性受体.细胞因子释放综合征 细胞因子释放综合征疾病机制 疾病机制免疫调节疗法 免疫调节治疗系统生物学 系统生物学

更多相关视频

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.5K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K

相关实验视频

Last Updated: Jun 5, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.5K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.4K

科学领域:

  • 毒理学 毒理学 毒理学
  • 系统生物学 系统生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 改善免疫调节疗法的非临床安全性评估至关重要.
  • 目前的方法需要加强对免疫毒理学不良结果的预测能力.

研究的目的:

  • 开发和说明系统免疫毒理学工作流程,以建模和预测不良结果.
  • 将不良结果路径 (AOP) 概念与系统医学疾病地图相结合.

主要方法:

  • 使用系统生物学格式将线性AOP扩展到分子相互作用模型中.
  • 作为一个用例,利用嵌合抗原受体 (CAR) T 细胞治疗.
  • 开发免疫毒性事件的知识整合和管理系统.

主要成果:

  • 创建了AOPs的结构化,数字化表示,超越图形插图.
  • 工作流程使免疫毒理学知识的集成,编码,管理和探索成为可能.
  • 通过MINERVA平台提供在线互动地图,供社区使用.

结论:

  • 开发的工作流程将AOP转换为标准化,可计算的格式,支持可重复的研究.
  • 该系统有助于随着研究的发展而扩大和更新知识.
  • 这种方法增强了对免疫调节疗法安全性的预测性评估.