与匹配的比较者相比,与酒精有关的肝病的急性胰腺炎风险增加了六倍:基于人口的队列研究
Ana Dugic1,2, Linnea Widman1, J-Matthias Löhr1,3,4
1Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Journal of internal medicine
|December 10, 2024
概括
与酒精相关的肝病 (ALD) 患者患胰腺炎的风险明显更高. 这项研究发现,ALD诊断前胰腺炎的几率增加了9倍,诊断后急性胰腺炎的住院率增加了6倍.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 与酒精有关的肝病 (ALD) 是一个重大的健康问题.
- ALD和急性胰腺炎 (AP) 之间的关联需要进一步的大规模调查.
研究的目的:
- 在被诊断患有与酒精有关的肝病的患者中调查胰腺炎的风险.
- 量化ALD队列中的胰腺炎的流行率和发病率.
主要方法:
- 一个基于人口的队列研究,利用瑞典国家患者登记册 (1969-2020).
- 包括37,062名患有ALD的患者,与352,931名普通人群对照者匹配.
- 使用后勤和考克斯回归模型来评估ALD诊断前后的胰腺炎风险.
主要成果:
- 与对照组相比,患有ALD的患者以前胰腺炎的几率高出9倍.
- 在10年内,AP住院的累计发病率在ALD患者中为2.7%,而在对照患者中为0.6% (aHR 6.3).
- 在ALD中AP的独立风险因素包括年轻年龄,男性性别,酒精使用障碍,COPD和持续饮酒.
结论:
- 与酒精有关的肝病与患有流行性胰腺炎和发生性胰腺炎的风险大幅增加密切相关.
- 大约10%的ALD患者经历或发展胰腺炎,强调需要对胰腺炎史进行临床评估.
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