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Updated: Jun 5, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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异构3DBicyclo[1.1.1] (BCP) 基于核的脂质用于mRNA传递和CRISPR/Cas基因编辑

Shiying Wu1, Yangyang Yang1, Xizhen Lian1

  • 1Department of Biomedical Engineering, Department of Biochemistry, Simmons Comprehensive Cancer Center, Program in Genetic Drug Engineering, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.

Journal of the American Chemical Society
|December 10, 2024
PubMed
概括

研究人员使用双环[1.1.1] (BCP) 核心开发了新的三维 (3D) 电离性脂质,以增强信使RNA (mRNA) 的传递. 与传统的2D设计相比,这些3D脂质显著提高了体内mRNA和基因编辑的治疗效率.

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