腕脉冲波速作为糖尿病发展的预测因素:在低风险人群中,正常范围内的高风险值
Jeonggyu Kang1,2, Ki-Hyun Jeon3, Kang-Un Choi4
1Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital Sungkyunkwan University, School of Medicine Seoul Republic of Korea.
Journal of the American Heart Association
|December 10, 2024
概括
腕脉冲波速度 (baPWV) 的升高是糖尿病和胰岛素耐药性发展的重要危险因素. 这种风险在女性中明显高,强调了动脉硬在代谢健康中的作用.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 最近的研究表明,脚脉冲波速度 (baPWV) 和糖尿病风险增加之间存在联系.
- 需要进一步的研究来了解不同性别和年龄组之间的这种关系.
研究的目的:
- 研究脚脉冲波速度 (baPWV) 与患糖尿病和胰岛素抵抗的风险之间的关联.
- 探索这种关联中潜在的基于性别的差异.
主要方法:
- 一项针对119,170名没有基线糖尿病的韩国成年人进行的大型队列研究.
- 在健康查期间进行了baPWV测量,并对糖尿病诊断和胰岛素抵抗标志物进行了随访.
- 使用灵活的参数比例危险模型,按性别和年龄分层.
主要成果:
- 总共有5966名参与者 (5.0%) 在5.6年的中位数随访期间患上糖尿病.
- 较高的baPWV四分位数与糖尿病发病风险增加显著相关 (HR为Q4vsQ1:1.48;P趋势<0.001).
- 观察到性别的显著相互作用,女性患糖尿病的风险更高;更高的baPWV也与胰岛素抵抗增加相关.
结论:
- 升高的baPWV,表明动脉硬,是糖尿病和胰岛素耐药性的重要预测因素.
- baPWV与糖尿病风险之间的关联在女性中尤为明显.
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