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迈向负担得起的生物医学成像:近期低成本,高分辨率的光声学显微镜的进展

Pavlos Kalitsounakis¹, Giannis Zacharakis², George J Tserevelakis^1,2

¹Department of Biology, University of Crete, Voutes University Campus, Heraklion, Crete, Greece.

Journal of microscopy

|December 10, 2024

概括

低成本的激光二极管正在彻底改变光声学显微镜 (OAM),使高分辨率成像更容易获得. 这一进步提高了生物医学研究应用的多谱能力,稳定性和可移植性.

科学领域:

生物医学光学生物医学光学
显微镜的使用方法
声学成像声学成像

背景情况:

光声显微镜 (OAM) 传统上使用昂贵的Q开关纳秒激光器.
这限制了先进的成像技术的广泛采用和可访问性.

研究的目的:

审查最近在低成本,高分辨率的光声学显微镜系统的进展.
突出激光二极管的集成作为信号激发的成本有效的替代方案.

主要方法:

讨论基于激光二极管的OAM的时间域和频域实现.
对系统性能和特定应用的调整进行分析.

主要成果:

与传统来源相比,激光二极管集成可降低20-40倍的成本.
在成本效益,多光谱能力,强度和便携性方面取得了明显的改进.
在微血管成像,氧和和多普勒流量测量的成功应用.

结论:

基于激光二极管的OAM系统在成本效益和性能方面取得了显著的飞跃.
这些系统非常适合各种生物医学研究,包括体内和体外研究.
进一步分析确定了不同激光二极管OAM方法的最佳应用环境.

关键词:

频率域是一个频率域.激光二极管激光二极管是什么低成本的低成本的成本.显微镜显微镜是一种微观的仪器.视听声学视听声学视听声学视听声学视听声学摄影声学摄影声学

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