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Updated: Jun 5, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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探索扩展弹头,以开发氨酸向的共价激酶抑制剂

Zheng Zhao1, Philip E Bourne1

  • 1School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States.

Journal of chemical information and modeling
|December 10, 2024
PubMed
概括

药物化学家现在可以探索新的电友化学空间来设计共价激酶抑制剂 (CKIs). 本研究分析了扩展弹头,提供了指导CKI开发的见解.

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