动态敏感性对比QIBA概况MRI定量成像生物标志物用于评估质瘤
Mark S Shiroishi1, Bradley J Erickson1, Leland S Hu1
1From the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).
动态敏感性对比 (DSC) MRI相对脑血量 (rCBV) 对于质瘤监测至关重要. 一个新的RSNA配置文件为纵向rCBV测量建立了精度要求,提高了临床使用的可重复性.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 动态敏感性对比 (DSC) MRI测量相对脑血量 (rCBV),对于跟踪质瘤进展和治疗反应至关重要.
- 目前的rCBV量化在不同环境中的可重现性面临挑战,阻碍了临床应用.
- RSNA DSC MRI 生物标志物委员会旨在标准化 rCBV 测量精度.
研究的目的:
- 建立基于统计数据的说法,以确定质瘤中纵向rCBV测量的精度.
- 解决临床和研究环境中rCBV量化可重复性的关键障碍.
- 为在质瘤患者中提供可靠的纵向DSCMRI分析提供框架.
主要方法:
- 专注于在对比剂度-时间曲线 (AUC) 值下的组织正常化区域的可重复性.
- 从以前的报告中利用了用于增强质瘤 (wCV=0.31) 和正常灰质 (wCV=0.40) 的患者内部变化系数 (wCV) 数据.
- 用95%的可靠性定义了纵向rCBV测量的特定百分比变化值.
主要成果:
- 对于增强质瘤,组织正常化AUC的增加>182%或减少>64%表明95%的信心具有显著的变化.
- 对于正常的灰质,在组织正常化的AUC中增加>399%或减少>80%表明有95%信心的显著变化.
- 这些说法为评估rCBV的纵向变化提供了客观的标准.
结论:
- 开发的RSNA配置文件为纵向rCBV测量提供了标准化的精度要求.
- 这种标准化对于DSC MRI在质瘤管理中的常规临床和试验使用至关重要.
- 未来的更新将纳入技术进步,以进一步完善生物标志物的精度.


