出院后营养状况的变化预测了来自PURSUIT-HFpEF注册表的急性不补偿HFpEF患者的预后
Takashi Kitao1, Shungo Hikoso2, Shunsuke Tamaki3
1Department of Cardiology, Minoh City Hospital, 5-7-1 Kayano, Minoh, Osaka, 562-0014, Japan. tk440515@yahoo.co.jp.
Heart and vessels
|December 10, 2024
概括
根据CONUT分数评估的营养状况的变化,显著影响了心力衰竭的结果,其中包括保留喷射分数 (HFpEF) 患者. 释放后改善营养会降低死亡率和再接收风险,而营养状况恶化会增加死亡率和再接收风险.
科学领域:
- 心脏病学和心血管疾病.
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 营养不良是心力衰竭的已知不良预后指标,心力衰竭的预后指标是保存的喷射分数 (HFpEF).
- 随着时间的推移,营养状况的变化对HFpEF预后的影响仍然不太清楚.
研究的目的:
- 研究由控制营养状况 (CONUT) 评分评估的营养状况变化的预后意义,从医院出院到HFpEF患者出院后的一年.
- 确定营养状况正常化或异常化的预测因素以及与CONUT分数变化相关的因素.
主要方法:
- 一组547名HFpEF患者的营养状况被评估,使用出院时的CONUT分数和出院后的一年.
- 患者被分为正常营养 (CONUT分数0-1) 和营养不良 (CONUT分数≥2) 的两组.
- 考克斯比例危险和后勤回归模型用于分析主要终点 (所有原因死亡率或HF再入院率) 和营养状况变化的预测因素.
主要成果:
- 出院后CONUT得分异常与初级终点风险增加2.87倍有关 (调整后HR:2.87).
- 康得分的正常化与0.40倍降低的风险有关 (调整后HR:0.40).
- 异常的预测因素包括营养良好患者的Euro Qol 5维分数,而之前的HF住院预测营养不良患者的正常化. 血红蛋白,C反应蛋白和NT-proBNP水平与CONUT得分变化相关.
结论:
- 出院后营养状况的变化 (CONUT评分) 显著影响HFpEF患者的预后.
- 监测和改善放出后的营养状况对于更好的HFpEF结果至关重要.
- CONUT分数的动态反映了与血液形成,炎症和液体平衡相关的潜在生理变化.
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