饮食中的胡卜素和生物衰老加速之间的关联:来自NHANES 2009-2018年的见解
Xinyun Chen1, Chunying He2, Wenhui Yu2
1Department of Health Management, Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Biogerontology
|December 10, 2024
概括
摄入更多的食类胡卜素,如β-胡卜素,与缓慢的生物衰老有关. 这些天然色素可以防止与年龄相关的衰退,促进更健康的衰老.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 胡卜素是具有抗氧化特性的重要植物颜料.
- 某些类胡卜素是维生素A的前体,对视力和免疫力至关重要.
- 胡卜素与降低与年龄相关疾病和健康衰老的风险有关.
研究的目的:
- 为了研究饮食中的胡卜素摄入量与生物衰老加速之间的关联.
- 为了确定可能影响衰老过程的特定胡卜素.
主要方法:
- 利用国家健康和营养检查调查 (NHANES) 数据 (2009-2018) 来自19,280名参与者.
- 使用表型年龄 (PhenoAge) 和克莱梅拉-双倍法 (KDM) 测量生物年龄.
- 采用加权多变量回归,限制立方线,子组,相互作用和WQS分析.
主要成果:
- 较高的食类胡卜素摄入量与较低的表型衰老加速相关.
- 阿尔法 - 胡卜素,β - 胡卜素,β - 克里普托桑丁,黄蛋白,紫素和柳科显示出保护作用.
- 通过WQS分析,β-胡卜素和β-素被确定为最有影响力的化合物.
结论:
- 饮食中的胡卜素与生物衰老加速的减少有关,这表明它在衰老中起着保护作用.
- 特定的胡卜素,特别是β-胡卜素和β-素,可能是这些抗衰老功效的关键.
- 建议进行进一步的纵向研究,以确认因果关系和阐明机制.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Mitochondria
10.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
10.9K


