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在神经退行性疾病和中枢神经系统损伤中,微质编程细胞死亡

Ling Cai¹, Qiuyue Fan¹, Rui Pang¹

¹Department of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Apoptosis : an international journal on programmed cell death

|December 10, 2024

概括

微中的编程细胞死亡 (PCD) 在中枢神经系统 (CNS) 疾病中起着关键作用. 准微质PCD通路为神经退行性疾病和中枢神经系统损伤提供了潜在的治疗策略.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

编程细胞死亡 (PCD) 是疾病发病的关键调节者.
中枢神经系统 (CNS) 的免疫细胞微细胞在中枢神经系统疾病中经历各种PCD途径 (死,烧,,铁,自).
失调的微质PCD有助于神经元损伤,并通过炎症级联加剧中枢神经系统病理.

研究的目的:

审查微质中PCD的机制及其在神经退行性疾病和中枢神经系统损伤中的作用.
提供针对微质PCD通路的当前抑制剂的系统概述.

主要方法:

关于微质PCD机制的最新发现的文献综述.
对各种PCD途径的治疗标和抑制剂的分析.

主要成果:

微质PCD与中枢神经系统病理的开始和进展有关.
微质PCD通路的异常激活会放大炎症和组织损伤.
已经确定了几种向不同PCD途径的抑制剂.

结论:

向微质PCD是中枢神经系统疾病的一个有前途的治疗策略.
对这些抑制剂的进一步研究可能会导致神经退行性疾病和中枢神经系统损伤的新疗法.

关键词:

在CNS的损害.微质细胞中的微质细胞神经退行性疾病是一种神经退行性疾病.神经炎症是一种神经炎症.编程细胞死亡编程细胞死亡

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