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Updated: Jun 5, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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在质母细胞瘤病因学中BRCA1的作用

Emirhan Harbi1, Michael Aschner2

  • 1Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. emirhanharbi41@gmail.com.

Cellular oncology (Dordrecht, Netherlands)
|December 10, 2024
PubMed
概括

质母细胞瘤中的BRCA1基因变异会损害DNA修复,推动瘤生长和治疗耐药性. 针对BRCA1通路,包括PARP抑制剂,为这种具有挑战性的癌症提供了新的治疗途径.

关键词:
这就是BRCA1的原因.DNA 修复机制的修复机制质母细胞瘤 (glioblastoma) 是一个

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