转录组和Pseudotrichomonas keilini的进化分析,这是一个自由生活的厌氧真核生物
Hend Abu-Elmakarem1, Stephen J Taerum2, Celine Petitjean3
1Institute of Ecology and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
Genome biology and evolution
|December 10, 2024
概括
来自自由生活的Pseudotrichomonas keilini的基因组数据显示,它的新陈代谢与寄生虫相似. 这表明寄生虫Trichomonas vaginalis血统在其生活方式过渡期间经历了更多的基因组变化.
科学领域:
- 简介:真核生物的进化过程.
- 无氧的真核生物是无氧的真核生物.
- 进行比较的基因组学.
背景情况:
- 早期的真核生物进化和适应低氧环境仍然是关键的生物学问题.
- 来自多种类型的真核生物,特别是自由生活的真核生物的基因组规模数据对于理解这些适应是至关重要的.
- 帕拉巴萨利亚,一个主要的无氧真核生物群,在自由生活物种的基因组数据中表现不佳.
研究的目的:
- 为了测序自由生活的抛物线动物Pseudotrichomonas keilini的转录组.
- 为了比较P. keilini的基因组数据与它的寄生虫亲属,如Trichomonas vaginalis.
- 在Parabasalia中推断进化轨迹和代谢适应.
主要方法:
- 转录基因组测序Pseudotrichomonas keilini. 的一个例子.
- 在P. keilini和Trichomonas vaginalis之间进行了比较基因组分析.
- 遗传学分析以确定P. keilini. 的进化位置.
主要成果:
- 伪基尼尼与Trichomonas vaginalis具有重要的代谢和基因补充相似之处.
- 在Trichomonas vaginalis血统中,有证据表明分歧后基因组发生了更大的变化,这可能是由寄生虫适应所驱动的.
- 这两种物种都具有基体和完整的糖解路径,表明保存的无氧能量代谢.
结论:
- 假基林尼 (Pseudotrichomonas keilini) 提供了对类动物祖先状态的洞察.
- 这项研究支持这样一个假设,即类动物是从一个内生祖先进化而来的,他们的血统适应了自由生活或寄生者的生活方式.
- 比较基因组学突出了生活方式转变对真核生物基因组进化的影响.
更多相关视频
10:18A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
Published on: April 25, 2015
10.3K
11:23Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
37.2K
相关概念视频
01:15Diversity of Protists I
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
02:05Gene Evolution - Fast or Slow?
7.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.0K
03:21Genome Size and the Evolution of New Genes
2.4K
2.4K
01:53Bacterial Transcription
28.0K
RNA polymerase (RNAP) carries out DNA-dependent RNA synthesis in both bacteria and eukaryotes. Bacteria do not have a membrane-bound nucleus. So, transcription and translation occur simultaneously, on the same DNA template.
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
28.0K
01:24Bacterial Phylum Tenericutes
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
02:54Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K