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皮肤细胞衰老和EndMT在接受环胺或HSCT治疗的全身性硬化症患者

Yu-Hsiang Chiu^1,2, Marijke van Dijk³, Roel Goldschmeding³

¹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.

Rheumatology (Oxford, England)

|December 10, 2024

概括

自主造血干细胞移植 (aHSCT) 和循环胺 (CYC) 在全身性硬化症 (SSc) 中降低了皮肤加厚和内皮转介质转变 (EndMT). 与CYC相比,aHSCT对EndMT和纤维化有更明显的影响.

科学领域:

类风湿病学类风湿病学
皮肤病学皮肤病学
细胞生物学细胞生物学

背景情况:

细胞衰老和内皮转介质转变 (EndMT) 是系统性硬化症 (SSc) 中的关键性益纤维化过程.
治疗对SSc中这些细胞通路的影响在很大程度上仍然未被描述.

研究的目的:

研究自身造血干细胞移植 (aHSCT) 和脉冲环胺 (IV CYC) 对分散皮肤SSc (dcSSc) 细胞衰老和EndMT的影响.
为了将治疗反应与特定的细胞标记物和组织病理学发现相关联.

主要方法:

在接受aHSCT或IV CYC治疗的dcSSc患者的皮肤活检在治疗前和治疗后6个月被分析.
组织病理学检查评估了纤维化,炎症,衰老,EndMT和组织重塑,包括PAR,P21和CTGF等标志物.

主要成果:

两种aHSCT和IV CYC治疗都导致皮肤加厚 (修改的罗丹皮肤评分) 和EndMT显著减少.
与IV CYC相比,aHSCT显示EndMT和纤维化标志物的下降更明显.
治疗反应不佳与CTGF和P21的特定基线水平以及治疗后这些标志物的变化有关.

结论:

aHSCT和iv CYC有效降低dcSSc患者的皮肤纤维化和减弱EndMT.
虽然这两种治疗都影响了EndMT,但细胞衰老在两组之间没有显著改变.
EndMT,UPAR,CTGF和血管性是SSc中纤维化活动和治疗反应的关键指标.

关键词:

自体血造干细胞移植血造干细胞移植纤维化纤维化病理学的病理学硬化皮质硬化皮质 (scleroderma) 是一种疾病.衰老是一种老化.系统性硬化症系统性硬化症

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