不孕症与分娩后发生的全身性自身免疫性类风湿性疾病之间的关联:基于人口的队列研究
Natalie V Scime1,2, Maria P Velez2,3, May Y Choi4
1Department of Health and Society, University of Toronto Scarborough, Toronto, ON, Canada.
Human reproduction (Oxford, England)
|December 10, 2024
概括
没有生育治疗的不孕症会增加分娩后妇女患全身性自身免疫性风湿性疾病 (SARD) 的风险. 通过识别这种联系,可以改善早期SARD检测.
科学领域:
- 风湿病学和免疫学
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 不孕症是一个日益关注的问题,也是女性慢性健康问题的潜在指标.
- 在患有不孕症的女性中观察到异常免疫活性,但其与全身自身免疫性类风湿性疾病 (SARD) 的联系仍未得到充分研究.
研究的目的:
- 调查不孕不育,有或没有生育治疗和产后女性系统性自身免疫性风湿性疾病 (SARD) 发生率之间的关联.
主要方法:
- 在加拿大安大略省 (2012-2021) 进行的一项基于人口的队列研究包括超过465,000名年龄在18-50岁的女性,她们以前没有SARD.
- 不孕不育被分为:没有不孕不育,不治疗不孕不育,非侵入性生育治疗和侵入性生育治疗 (IVF/ICSI).
- 系统性自身免疫性类风湿性疾病 (SARD) 的发病被使用经过验证的行政健康数据算法确定.
主要成果:
- 患有不孕症但不接受生育治疗的女性,与没有不孕症的女性相比,SARD的发病率更高.
- 在没有治疗的不孕症妇女中,SARD的风险仍然很高,即使经过对不良妊娠结果进行调整 (HR 1.25).
- 无论是非侵入性还是侵入性生育治疗,都没有与SARD的风险增加显著相关.
结论:
- 不孕症,特别是当不用生育干预治疗时,可能成为分娩后妇女SARD的重要风险标志物.
- 医疗保健提供者对患有不孕症的女性SARD症状的提高认识可能会导致更早的诊断和管理.
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